Educational dose math only — not medical advice, not a product recommendation, and not a pass/fail on whether a supplement will work for you.
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Nine RCTs, 200–1000 µg/day chromium picolinate, 8–24 weeks. Body weight MD −1.1 kg (95% CI −1.7 to −0.4). Low-quality GRADE; debatable clinical relevance; no dose gradient.

Educational only — not medical advice. Disclaimer.

Want the outcome before the arithmetic? The reason check opens any registry entry on this page with its trial result first, then compares your daily intake with the studied amount.

NIH DSLD market slice

Median200 mcg
Products138
Below76%

Bulk CSV dump 16 January 2026 · label entries through 2025. Disclosed amounts only — proprietary blends without gram weights excluded.

Trial floors

Primary

Cochrane weight review (pooled doses) · 1,000 mcg over 12-16 weeks (limited evidence · how we grade this) · Significant, low-quality evidence — Nine RCTs, 200–1000 µg/day chromium picolinate, 8–24 weeks. Body weight MD −1.1 kg (95% CI −1.7 to −0.4). Low-quality GRADE; debatable clinical relevance; no dose gradient.

Secondary

Pittler 2003 sensitivity analysis · 1,000 mcg over 12-16 weeks (limited evidence · how we grade this) · Primary endpoint missed — Removing one influential trial: −0.9 kg (95% CI −2.0 to 0.2), not statistically significant. Funnel plot asymmetry suggests publication bias.

Safety red flags

  • Tell your prescriber you take chromium, especially if you have episodes of low blood sugar.
  • Do not treat chromium as a substitute for glucose monitoring.

Label reading notes

  • Picolinate is not interchangeable with chromium polynicotinate or generic chromium on labels.
  • Cochrane rated evidence low-quality; shelf math does not mean clinically meaningful weight loss.
  • Does not address H1-driven appetite from mirtazapine; metabolic lever only.
  • Stay within the 200–1000 µg/day studied range; case reports of renal issues at very high chronic doses.