Educational dose math only — not medical advice, not a product recommendation, and not a pass/fail on whether a supplement will work for you.
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Trial reference

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Active dose is EPA + DHA on the Supplement Facts panel — not total fish oil weight. This range is the span of doses pooled across 68 RCTs and 32 meta-analyses; neither review identifies a single threshold dose, and the CRP effect weakened above BMI 30.

Educational only — not medical advice. Disclaimer.

Want the outcome before the arithmetic? The reason check opens any registry entry on this page with its trial result first, then compares your daily intake with the studied amount.

NIH DSLD market slice

Median0.6 g
Products7,305
Below76%

Bulk CSV dump 16 January 2026 · label entries through 2025. Disclosed amounts only — proprietary blends without gram weights excluded.

Trial floors

Primary

OTC inflammatory-marker meta-analyses (EPA+DHA) · 1–2 g (medium evidence · how we grade this) · Benefit shown — Active dose is EPA + DHA on the Supplement Facts panel — not total fish oil weight. This range is the span of doses pooled across 68 RCTs and 32 meta-analyses; neither review identifies a single threshold dose, and the CRP effect weakened above BMI 30.

Other floors

  • EPA dose-finding in inflammatory depression · 4 g over 12 weeks (limited evidence · how we grade this) · Primary endpoint missed — EPA-only, in adults with major depression plus BMI over 25 and hs-CRP at or above 3 mg/L. Response was 64% vs 40% on placebo (Cohen d = 0.53) but not statistically significant, and the prespecified IL-6 and TNF endpoints were missed. A dose-finding signal in a narrow phenotype, not an established dose.

  • REDUCE-IT (prescription icosapent ethyl) · 4 g (high evidence · how we grade this) · Benefit shown — Prescription purified EPA — not comparable to a standard fish oil capsule.

Safety red flags

  • On warfarin, a DOAC, or an antiplatelet: mention high-dose fish oil to your prescriber and keep the dose stable.
  • Tell your prescriber about high-dose fish oil before any planned procedure.

Label reading notes

  • Read EPA and DHA separately on the Supplement Facts panel. Total fish oil grams or "1000 mg fish oil" is not the active dose.
  • Oxidation matters. Look for TOTOX, peroxide value, or third-party freshness testing; rancid oil wastes the milligrams.
  • Mood and inflammation trials point at EPA-heavy preparations in specific phenotypes. A 1:1 EPA:DHA blend at 1 g total often under-delivers EPA relative to the dose-finding work.