Educational dose math only — not medical advice, not a product recommendation, and not a pass/fail on whether a supplement will work for you.
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15 mg twice daily in men whose depression was already stabilised on fluoxetine. Erectile function and intercourse satisfaction improved; orgasmic function, overall satisfaction and desire did not. Thirty completers in a single Iranian centre.

Educational only — not medical advice. Disclaimer.

Want the outcome before the arithmetic? The reason check opens any registry entry on this page with its trial result first, then compares your daily intake with the studied amount.

NIH DSLD market slice

Median30 mg
Products250
Below46%

Bulk CSV dump 16 January 2026 · label entries through 2025. Disclosed amounts only — proprietary blends without gram weights excluded.

Trial floors

Primary

Fluoxetine-related sexual dysfunction, men · 30 mg over 4 weeks (limited evidence · how we grade this) · Benefit shown — 15 mg twice daily in men whose depression was already stabilised on fluoxetine. Erectile function and intercourse satisfaction improved; orgasmic function, overall satisfaction and desire did not. Thirty completers in a single Iranian centre.

Other floors

  • Fluoxetine-related sexual dysfunction, women · 30 mg over 4 weeks (limited evidence · how we grade this) · Benefit shown — Same 30 mg/day in women stabilised on fluoxetine 40 mg. Total FSFI, arousal, lubrication and pain improved; desire did not. Separate trial, separate instrument — do not read the men's result into this one or the reverse.

  • Postpartum depression, saffron vs fluoxetine · 30 mg over 6 weeks (limited evidence · how we grade this) · Primary endpoint missed — 15 mg twice daily against fluoxetine 20 mg twice daily in mild-to-moderate postpartum depression. There was no significant difference between arms, and complete response was 40.6% on saffron vs 50.0% on fluoxetine — an active-comparator trial with no placebo arm, so it does not establish that saffron beat nothing.

  • Depression meta-analyses (pooled) · 30 mg (limited evidence · how we grade this) · Primary endpoint missed — Pooled saffron-vs-placebo effect was large but the confidence interval reached zero (SMD −0.86, 95% CI −1.73 to 0.00), and saffron did not differ from fluoxetine. Eight small trials, most from a single country. Treat 30 mg/day as the dose those trials used, not as a settled effective dose.

Label reading notes

  • Almost every trial used 30 mg per day of a standardised extract — check whether the label means extract or dried stigma powder.
  • Branded standardised extracts (affron, Safr'Inside) are dosed at 28-30 mg; raw powder blends at the same milligram count are not the same material.
  • Trials ran 4-6 weeks in people already on an antidepressant, under clinician care. Do not stop or change a prescription to try this.